ea0022p717 | Obesity | ECE2010
Vila Greisa
, Kiefer Florian
, Reiter Marie Helene
, Zeyda Maximilian
, Stulnig Thomas M
, Luger Anton
Serum and glucocorticoid-induced kinase 1 (Sgk1) is an early transcriptional target of glucocorticoids with antiapoptotic effects. Sgk1 becomes active after phosphorylation by growth factors such as insulin and IGF1 through the PI3 kinase/PDK1 pathway. Activated Sgk1 increases the cellular uptake of glucose by increasing the membrane abundance of glucose transporters GLUT1 and GLUT4. Here we present data on the expression and regulation of Sgk1 in adipose tissue using three di...